Sucralfate-containing composition and process for the preparation thereof
AssigneesChugai Seiyaku Kabushiki Kaisha, Fuji Chemical Industry Co., Ltd.
InventorsTamotsu Yamazaki, Heiji Ikushima, Tetsuo Shirai
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Abstract
A coated antacid comprising sucralfate and an antacid inhibits decline in the adhesion characteristics of sucralfate whereby the drug ingested can reliably show its effect in the stomach. This coated antacid not only shows the mucosa repairing effect of sucralfate itself, but also shows the antacid effect and the gastric mucosa protective effect of the coated antacid, thereby synergistically producing an excellent antiulcer effect and an excellent ulcer inhibiting/healing effect.
Claims20
A pharmaceutical composition for delayed release of an antacid in the stomach, in unit dosage form comprising (A) 300-1200 mg of sucralfate, and (B) 500-1400 mg of a coated antacid,
- wherein the coating of said coated antacid is a cellulose derivative or a synthetic polymeric compound which is not easily dissolvable in the presence of gastric juice.
A pharmaceutical composition for delayed release of an antacid in the stomach, consisting essentially of
- (A) 300-1200 mg of sucralfate,
- (B) 500-1400 mg of a coated antacid, and
- (C) a drug selected from the group consisting of stomachics, digestives, cholagogues, gastric mucosa protectives, acetylcholine inhibitors, and local anesthetics,
- wherein the coating of said coated antacid is a cellulose derivative or a synthetic polymeric compound which is not easily dissolvable in the presence of gastric juice.
A pharmaceutical composition for delayed release of an antacid in the stomach, consisting essentially of
- (A) 300-1200 mg of sucralfate, and
- (B) 500-1400 mg of a coated antacid,
- wherein the antacid of said coated antacid is an antacid selected from the group consisting of magnesium aluminometalsilicate, magnesium aluminosilicate, synthetic hydrotalcite, synthetic aluminum silicate, magnesia alumina hydrate, aluminum hydroxide-sodium bicarbonate coprecipitate, aluminum hydroxide-magnesium carbonate-calcium carbonate coprecipitate, dried aluminum hydroxide gel and precipitated calcium carbonate,
- wherein the coating of said coated antacid is a cellulose derivative or a synthetic polymeric compound which is not easily dissolvable in the presence of gastric juice.
A pharmaceutical composition for delayed release of an antacid in the stomach, consisting essentially of
- (A) 300-1200 mg of sucralfate,
- (B) 500-1400 mg of a coated antacid, and
- (C) a drug selected from the group consisting of stomachics, digestives, cholagogues, gastric mucosa protectives, acetylcholine inhibitors and local anesthetics, wherein the antacid of said coated antacid is an antacid selected from the group consisting of magnesium aluminometasilicate, magnesium aluminosilicate, synthetic hydrotalcite, synthetic aluminum silicate, magnesia alumina hydrate, aluminum hydroxide-sodium bicarbonate coprecipitate aluminum hydroxide-magnesium carbonate-calcium carbonate coprecipitate, dried aluminum hydroxide gel and precipitated calcium carbonate,
- wherein the coating of said coated antacid is a cellulose derivative or a synthetic polymeric compound which is not easily dissolvable in the presence of gastric juice.
Dependencies are inferred from the claim text.