Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Jacek Bigda, Igor Beletsky, Igor Mett, Hartmut Engelmann
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Abstract
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.
Claims3
A method of inhibiting the cytocidal effect of TNF without blocking TNF binding to the p75 TNF receptor (residues 27-210 of SEQ ID NO:2), comprising bringing to the vicinity of the p75 TNF receptor a peptide or antibody comprising the antigen binding portion of an antibody which binds to the fourth cysteine rich domain of the p75 TNF receptor, which domain consists of the sequence of amino acid residues 163 to 201 of SEQ ID NO:2, or to the region between said fourth cysteine rich domain of the p75 TNF receptor and the cell membrane, which region consists of the sequence of amino acid residues 201-257 of SEQ ID NO:2, with the proviso that said antigen binding portion is not that of a monoclonal antibody from the clone 67 (CNCM No. I-1368).
Dependencies are inferred from the claim text.