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US 6,552,246 B1Granted
Transgenic mice comprising CD45 knockout
AssigneeUniversity Health Network
InventorsTak Wah Mak, Josef Martin Penninger
Life of this patent
Estimating the term…
Abstract
A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.
Claims4
A mutant mouse wherein its endogenous CD45 gene has been disrupted using a DNA construct comprising exons 6-8 of the CD45 gene, wherein a marker sequence has been substituted for at least intron 6 and exon 6, and wherein disruption prevents expression of CD45 on B-cells and T-cells and results in a decreased cytotoxic T-cell response.
Dependencies are inferred from the claim text.