Process for preparing (+)-cis-sertraline
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsMarioara Mendelovici, Tamar Nidam, Gideon Pilarsky, Neomi Gershon
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Abstract
The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and about 12:1, from the Schiff base of sertralone, sertraline-1-imine.
Claims30
A process for making (±)-sertraline having a cis/trans ratio of greater than about 3:1 comprising the step of hydrogenating sertraline-1-imine at a temperature of at least about 40° C. using a catalyst selected from the group consisting of palladium and platinum.
Dependencies are inferred from the claim text.