Chemical compounds

A compound of formula (I):

• wherein:
• R1 and R2 are each selected independently from hydrogen, phenyl optionally substituted by one or more Q, naphthyl optionally substituted by one or more Q, C3-6cycloalkyl optionally substituted by one or more Q, C2-6alkenyl, C2-6alkynyl, C1-6alkyl optionally substituted by one or more Q, R8T—, R9C1-6alkylT— and a heterocyclic group optionally substituted on a ring carbon by one or more Q and wherein if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D,
• or R1 and R2 together with the nitrogen atom to which they are attached form a group Het which is optionally substituted on a ring carbon by one or more Q and wherein if group Het contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• R3 and R4 are independently Ckalkyl optionally substituted by 1 to 2k+1 atoms selected from fluoro and chloro wherein k is 1-3;
• or R3 and R4 together with the carbon atom to which they are attached, form a Cmcycloalkyl ring optionally substituted by 1 to 2m-2 fluorine atoms wherein m is 3-5;
• R5 is hydrogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, cyano, nitro, C2-6alkenyloxy, trifluoromethylthio, halo, hydroxy, amino, N—(C1-6alkyl)amino, N—(C1-6alkyl)2amino, C1-6alkanoylamino, C1-6alkanoyl(N—C1-6alkyl)amino, C1-6alkylsulphonylamino, C1-6alkylsulphonyl(N—C1-6alkyl)amino, thiol, C1-6alkylsulphanyl, C1-6alkylsulphinyl, C1-6alkylsulphonyl, sulphamoyl, N—(C1-6alkyl)aminosulphonyl, N—(C1-6alkyl)2aminosulphonyl, carboxy, carbamoyl, N—(C1-6alkyl)carbamoyl, N—(C1-6alkyl)2carbamoyl, C1-6alkoxycarbonyl, formyl, C1-6alkanoyl, C1-6alkanoyloxy, C2-6alkenyl or C2-6alkynyl;
• R6 is hydrogen or Q;
• R7 is hydrogen, trifluoromethyl, C1-4alkyl, halo, hydroxy, trifluoromethoxy, cyano, C1-4alkoxy, formyl, C1-4alkanoyl, C1-4alkanoyloxy, amino, N—(C1-4alkyl)amino, N—(C1-4alkyl)2amino, C1-4alkanoylamino, C1-4alkanoyl(N—C1-4alkyl)amino, nitro, carboxy, carbamoyl, ureido, C1-4alkoxycarbonyl, thiol, C1-4alkylsulphanyl, C1-4alkylsulphinyl, C1-4alkylsulphonyl, sulphamoyl, N—(C1-4alkyl)aminosulphonyl, N—(C1-4alkyl)2aminosulphonyl, N′—(C1-4alkyl)ureido or N′—(C1-4alkyl)2ureido;
• R8 is C1-6alkyl optionally substituted by one or more R10, C3-6cycloalkyl optionally substituted by one or more R10, phenyl optionally substituted by one or more R10, naphthyl optionally substituted by one or more R10 or a heterocyclic group optionally substituted on a ring carbon by one or more R10 and if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• R9 is phenyl optionally substituted by one or more R10, naphthyl optionally substituted by one or more R10 or a heterocyclic group optionally substituted on a ring carbon by one or more R10 and if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• R10 is C1-6alkyl-M— optionally substituted by R16, halo, hydroxy, cyano, formyl, amino, nitro, carboxy, carbamoyl, thiol, sulphamoyl, phenyl optionally substituted by R16, a heterocyclic group optionally substituted on a ring carbon by R16 wherein if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• Q is C1-6alkyl-M— optionally substituted with one or more R11, C2-6alkenyl-M— optionally substituted by one or more R11, C2-6alkynyl-M— optionally substituted by one or more R11, R13—M—, hydroxy, halo, cyano, thiol, sulphamoyl, nitro, carboxy, amino, carbamoyl, formyl or ureido;
• T is —O—, —C(O)—, —NH—,—N(N—C1-6alkyl)-, —C(O)NH—, —NHC(O)—, —C(O)N(N—C1-6alkyl)—, —N(N—C1-6alkyl)C(O)—, —SO2—, —C(S)—, —C(S)NH—, —NHC(S)—, —C(S)N(N—C1-6alkyl)- or —N(N—C1-6alkyl)C(S)—;
• M is —(O—, —N(R14)—, —C(O)—, —N(R14)C(O)—, —C(O)N(R14)—, —S(O)n— wherein n is 0-2, —OC(O)—,—C(O)O—, —N(R14)C(O)O—, —OC(O)N(R14), —C(S)N(R14)—, —N(R14)C(S)—, —SO2N(R14)—, —N(R14)SO2—, —N(R14)C(O)N(R14)—, —N(R14)C(S)N(R14)—, —SO2NHC(O)—, —SO2N(R14)C(O)—, —C(O)NHSO2—, —C(O)N(R14)SO2— or M is a direct bond;
• D is C1-6alkyl, C1-6alkanoyl, C1-6alkylsulphonyl, C1-6alkoxycarbonyl, carbamoyl, N—(C1-6alkyl)carbamoyl, N—(C1-6alkyl)2carbamoyl, benzoyl, (heterocyclic group)carbonyl, phenylsulphonyl, (heterocyclic group)sulphonyl, phenyl or a carbon linked heterocyclic group, and wherein any C1-6alkyl group may be optionally substituted by one or more R11, and wherein any phenyl or heterocyclic group may be optionally substituted on a ring carbon by one or more groups selected from R10 and if a heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from E;
• E is C1-6alkyl, C1-6alkanoyl, C1-6alkylsulphonyl, C1-6alkoxycarbonyl, carbamoyl, N—(C1-6alkyl)carbamoyl, N—(C1-6alkyl)2carbamoyl, C1-6alkoxyC1-6alkanoyl, phenylC1-6alkyl, benzoyl, phenylC1-6alkanoyl, phenylC1-6alkoxycarbonyl or phenylsulphonyl.
• R11 is hydroxy, nitro, cyano, thiol, halo, ureido, amino, N—(C1-6alkyl)amino, N—(C1-6alkyl)2amino, carboxy, C1-6alkoxy, carbamoyl, N—(C1-6alkyl)carbamoyl, N—(C1-6alkyl)2carbamoyl, formyl, sulphamoyl, N—C1-6alkylaminosulphonyl, N—(C1-6alkyl)2aminosulphonyl, C1-6alkylsulphonylamino, C1-6alkanoylamino, C1-6alkylsulphanyl, C1-6alkylsulphinyl, C1-6alkylsulphonyl, phenyl optionally substituted by one or more R10, naphthyl optionally substituted by one or more R10, or a heterocyclic group optionally substituted on a ring carbon by one or more R10 , and if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• R13 is phenyl optionally substituted by one or more R10, C3-6cycloalkyl optionally substituted by one or more R10, naphthyl optionally substituted by one or more R10, or a heterocyclic group optionally substituted on a ring carbon by one or more R10 and if said heterocyclic group contains an —NH— moiety that nitrogen may be optionally substituted by a group selected from D;
• R14 is hydrogen or C1-6alkyl optionally substituted by one or more R15 with the proviso that R15 is not a substituent on the carbon attached to the nitrogen atom of M;
• R15 is halo, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, N—(C1-6alkyl)amino, N—(C1-6alkyl)2amino, C1-6alkanoylamino, C1-6alkanoyl(N—C1-6alkyl)amino, C1-6alkylsulphonylamino, C1-6alkylsulphonyl(N—C1-6alkyl)amino, thio, C1-6alkylsulphanyl, C1-6alkylsuphinyl, C1-6alkylsulphonyl, sulphamoyl, N—(C1-6alkyl)aminosulphonyl, N—(C1-6alkyl)2aminosulphonyl, carboxy, carbamoyl, N—(C1-6alkyl)carbamoyl, N—(C1-6alkyl)2carbamoyl, C1-6alkoxycarbonyl, C1-6alkanoyl or formyl;
• R6 is hydroxy, halo, cyano, C1-6alkoxy, formyl, C1-6alkanoyl, C1-6alkanoyloxy, amino, N—(C1-6alkyl)amino, N—(C1-6alkyl)2amino, C1-6alkanoylamino, C1-6alkanoyl(N—C1-6alkyl)amino, carboxy, carbamoyl, C1-6alkoxycarbonyl, C1-6alkylsulphanyl, C1-6alkylsulphinyl, C1-6alkylsulphonyl, sulphamoyl, N—(C1-6alkyl)aminosulphonyl or N—(C1-6alkyl)2aminosulphonyl;
• and wherein if one of R5, R6 and R7 is hydrogen the others cannot be hydrogen;
• or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof.