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AssigneeRamot University Authority for Applied Research and Industrial Development Ltd.
InventorsMia Horowitz, Liat Mintz
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The present invention teaches novel Eps15 homology (EH) domain containing proteins, polynucleotide sequences encoding the novel EH domain containing proteins, oligonucleotides and oligonucleotide analogs derived from the polynucleotide sequences, a display library displaying short peptides derived from the EH domain containing proteins, antibodies recognizing the EH domain containing proteins, peptides or peptide analogs derived from the EH domain containing proteins, and pharmaceutical compositions and methods of employing the peptides or peptide analogs, the oligonucleotides and oligonucleotide analogs, and/or the polynucleotide sequences to up-regulate or down-regulate clathrin coated pit mediated endocytosis and thereby insulin growth factor 1 receptor (IGF1 receptor) signaling.
An isolated nucleic acid comprising a genomic, complementary or composite polynucleotide sequence encoding a polypeptide being functional in endocytosis in cells and being at least 80% homologous to SEQ ID NOs:4 or 5 as determined using the BestFit software of the Wisconsin sequence analysis package, utilizing the Smith and Waterman algorithm, where gap creation penalty equals 8 and gap extension penalty equals 2.
An isolated nucleic acid comprising a polynucleotide sequence as set forth in SEQ ID NOs:
An isolated nucleic acid comprising a polynucleotide sequence encoding a polypeptide as set forth in SEQ ID NOs:4 or 5.
Dependencies are inferred from the claim text.