Reagents and methods useful for detecting diseases of the breast
AssigneeAbbott Laboratories
InventorsTracy L. Colpitts, John C. Russell
Life of this patent
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Abstract
This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the breast such as breast cancer. Furthermore, the invention relates to methods and kits, for example, which utilize this antigen or an antibody thereto. The complex itself comprises at least one BU101 polypeptide and at least one Mammaglobin polypeptide. In addition, the complex may comprise at least one polypeptide having at least 20% identity with the amino acid sequence of the BU101 polypeptide, the amino acid sequence of the Mammaglobin polypeptide, and fragments thereof.
Claims7
A purified multimeric polypeptide antigen (MPA) comprising at least one BU101 polypeptide (SEQ ID NO:6) and at least one Mammaglobin polypeptide (SEQ ID NO:5), wherein said antigen has a molecular weight of about 20 to 70 kilodaltons.
A composition of matter comprising a multimeric polypeptide antigen, wherein said antigen comprises at least one BU101 polypeptide comprising the amino acid sequence of SEQ ID NO:6 and at least one Mammaglobin polypeptide comprising the amino acid sequence of SEQ ID NO:5.
A composition of matter comprising a multimeric polypeptide antigen, wherein said antigen comprises at least one BU101 polypeptide comprising the amino acid sequence of SEQ ID NO:6 and at least one Mammaglobin polypeptide comprising the amino acid sequence of SEQ ID NO:5, wherein said composition further comprises two antibodies and each binds to a separate polypeptide, wherein each of said two antibodies binds to a BU101 polypeptide comprising the amino acid sequence of SEQ ID NO:6.
A composition of matter comprising a multimeric polypeptide antigen, wherein said antigen comprises at least one BU101 polypeptide comprising the amino acid sequence of SEQ ID NO:6 and at least one Mammaglobin polypeptide comprising the amino acid sequence of SEQ ID NO:5, wherein said composition further comprises two antibodies and each binds to a separate polypeptide, wherein each of said two antibodies binds to a Mammaglobin polypeptide comprising the amino acid sequence of SEQ ID NO:5.
Dependencies are inferred from the claim text.