Compounds and methods of treating cell proliferative diseases

A compound having a general formula (I):

• wherein:
• R1 is CH2R3 or COR3;
• R2 represents a hydrogen atom or an alkenyl group containing from 3 to 6 carbon atoms;
• R3 is —OH, —OR4, —SR4, —NR5R6, or
• R4 represents a group selected from alkyl containing from 1 to 6 carbon atoms, aryl, aralkyl, alkanoyl from 2 to 6 carbon atoms and arylcarbonyl;
• R5 and R6, independently from each other, are selected from a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, an aryl and an aralkyl;
• m is 2 or 3;
• n represents an integer between 1 and 10 inclusive;
• X represents an oxygen atom, a sulfur atom or a radical —NR7—;
• Y represents an oxygen atom;
• R7, identical or different, is selected in a group consisting of a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, an aryl and an aralkyl;
• A represents either a substituted phenyl group of formula
• in which:
• R8, R9, R10 and R11, independently from each other, are selected from a hydrogen atom, a halogen atom (preferably F, Cl, or Br), a hydroxyl group, a (C1-C10)alkyl group, an (C1-C10)alkanoyl group, a (C1-C10)alkoxy group, an aryl group, an aralkyl group, an arylcarbonyl group, a mono- or poly-cyclic hydrocarbon group, —NO2, —CN, a —NR12R13 group or a trifluoro(C1-C6)alkyl group;
• R8, R9, R10 and R11, not being simultaneously hydrogen atom,
• or alternatively two substituents, R8 and R9, may form together a mono- or poly-cyclic hydrocarbon group with the carbon atoms of the phenyl group they are attached and the two other substituents, R10 and R11, are as defined above;
• or A represents a 5- or 6-membered heterocyclic ring which has 1 to 3 hetero-atoms selected from oxygen, sulfur and nitrogen, said ring is bonded directly to X;
• R12 and R13, independently from each other, are selected in the group consisting of a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, an aryl and an aralkyl;
• with the provisos that:
• when X is an oxygen atom, R2 is a hydrogen atom, n is 5 and R8 on the ortho position on the phenyl group is n-propyl group, then R9, R10 and R11 are different from hydrogen;
• when X is an oxygen atom, R2 is a hydrogen atom, n is 5, R8 on the ortho position on the phenyl group is n-propyl group, R9 on the meta position is an hydroxyl group, and R10 on the para position is an acetyl group;
• then R11 is different from hydrogen;
• when X is an oxygen atom, R2 is a hydrogen atom, n is 2 or 3, then A is different from a non-substituted naphthalene group;
• its optical isomers, geometrical isomers, salt, or hydrates thereof.