Methods for treating cell death diseases and inflammation
AssigneePresident and Fellows of Harvard College
InventorsJunying Yuan, Masuko Kobori, Zhen Yang
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Abstract
The present invention features methods and compounds for treating or preventing a cell death disease or inflammation, and methods for synthesizing wedelolactone.
Claims16
A method for treating or preventing a cell death disease in a subject, said method comprising administering wedelolactone, or a derivative or salt thereof, to said subject, wherein said cell death disease is not caused by hepatotoxicity.
A method for treating or preventing a septic shock in a subject, said method comprising administering wedelolactone, or a derivative or salt thereof, to said subject.
A method for treating or preventing septic shock in a subject, said method comprising administering to the subject a chemical compound in a pharmaceutically acceptable carrier, said compound having the formula:
- wherein R1 is selected from the group consisting of H, OH, and OCH3;
- and R2 is selected from the group consisting of H, CH3, and (CH2)XCH3, wherein x is a positive integer.
A method for treating or preventing a cell death disease in a subject, said method comprising administering to the subject a chemical compound in a pharmaceutically acceptable carrier, said compound having the formula:
- wherein R1 is selected from the group consisting of H, OH, and OCH3;
- and R2 is selected from the group consisting of H, Ch3, and (CH2)xCH3, wherein x is a positive integer, wherein said cell death disease is not caused by hepatotoxicity.
A method of synthesizing a 2,3-disubstituted benzo[b]furan, said method comprising subjecting a molecule having the formula:
- to carbonylative heteroannulation.
A method of synthesizing wedelolactone, said method comprising subjecting a molecule having the formula:
- to lactonization.
Dependencies are inferred from the claim text.