3-methyl-chroman and -thiochroman derivatives

A compound represented by Peak 1 or 2 shown in the following formula:

• wherein said Peaks 1 and 2 are detected at retention times of 32 and 38 minutes, respectively, when optically resolved and measured under the following conditions:
• Column used:
• CHIRALPAK AD (0.46 cm ID×25 cm L)
• Mobile phase:
• hexane/isopropanol/acetic acid=90/10/0.2 (v/v/v)
• Flow rate:
• 1.0 ml/min
• Column temperature:
• 40° C.
• Detection wavelength:
• 280 nm.

A compound represented by Peak 1 or 2 shown in the following formula:

• wherein said Peaks 1 and 2 are detected at retention times of 30 and 34 minutes, respectively, when optically resolved and measured under the following conditions:
• Column used:
• CHIRALPAK AD (0.46 cm ID×25 cm L)
• Mobile phase:
• hexane/isopropanol/acetic acid=90/10/0.2 (v/v/v)
• Flow rate:
• 0.8 ml/min
• Column temperature:
• 40° C.
• Detection wavelength:
• 280 nm.

A compound represented by Peak 1 or 2 shown in the following formula:

• wherein said Peaks 1 and 2 are detected at retention times of 17.5 and 20.7 minutes, respectively, when optically resolved and measured under the following conditions:
• Column used:
• CHIRALPAK AD (0.46 cm ID×25 cm L)
• Mobile phase:
• hexane/isopropanol/acetic acid=90/10/0.1 (v/v/v)
• Flow rate:
• 1.0 ml/min
• Column temperature:
• 40° C.
• Detection wavelength:
• 254 nm.

A compound represented by Peak 1 or 2 shown in the following formula:

• wherein said Peaks 1 and 2 are detected at retention times of 8.4 and 10.8 minutes, respectively, when optically resolved and measured under the following conditions:
• Column used:
• CHIRALPAK AD (0.46 cm ID×25 cm L)
• Mobile phase:
• hexane/isopropanol/acetic acid=80/20/0.1 (v/v/v)
• Flow rate:
• 1.0 ml/min
• Column temperature:
• 40° C.
• Detection wavelength:
• 254 nm.