US 6,552,068 B1 · 3-ethyl-, 3-propyl- or 3-butyl-chroman and thiochroman derivatives

Abstract

A compound having the following general formula (1): in which R1 represents an ethyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C5 perhalogenoalkyl group, etc.; each of R4 and R5 independently represents a hydrogen atom, etc.; X represents an oxygen atom or a sulfur atom; m represents an integer of 2 to 14; and n represents an integer of 2 to 7; or an enantiomer of the compound, or a hydrate or a pharmaceutically acceptable salt of the compound or its enantiomer is advantageous in pharmaceutical use because of its anti-estrogenic activity.

Claims20

Dependent claims

A compound having the following formula (1):

in which
R1 represents an ethyl group, a n-propyl group, an i-propyl group or a butyl group;
R2 represents a hydrogen atom or a salt-forming metal;
R3 represents a linear or branched C1-C7 halogenoalkyl group;
each of R4 and R5 independently represents a hydrogen atom, an optionally substituted linear or branched C1-C3 alkyl group, an acyl group or a salt-forming metal;
X represents an oxygen atom or a sulfur atom;
m represents an integer of 2 to 14;
and
n represents an integer of 2 to 7;
or an enantiomer of the compound, or a hydrate or a pharmaceutically acceptable salt of the compound or its enantiomer.

7 more elements

Dependencies are inferred from the claim text.

3-ethyl-, 3-propyl- or 3-butyl-chroman and thiochroman derivatives

Life of this patent

3-ethyl-, 3-propyl- or 3-butyl-chroman and thiochroman derivatives

Life of this patent

Abstract

Claims20