Deacetylase inhibitors

A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of formula (I)

• wherein
• R1 is H, halo, or a straight chain C1-C6 alkyl;
• R2 is selected from H, C1-C10 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, C4-C9 heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, —(CH2)nC(O)R6, —(CH2)nOC(O)R6, amino acyl, HON—C(O)—CH═C(R1)-aryl-alkyl- and —(CH2)nR7;
• R3 and R4 are the same or different and independently H, C1-C6 alkyl, acyl or acylamino, or R3 and R4 together with the carbon to which they are bound represent C═O, C═S, or C═NR8g;
• R5 is polyheteroaryl which is substituted or unsubstituted indol-3-yl;
• n, n1, n2 and n3 are the same or different and independently selected from 0-6, when n, is 1-6, each carbon atom can be optionally and independently substituted with R3 and/or R4;
• X and Y are the same or different and independently selected from H, halo, C1-C4 alkyl, NO2, C(O)R1, OR9, SR9, CN, and NR10R11;
• R6 is selected from H, C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, OR12, and NR13R14;
• R7 is selected from OR15, SR15, S(O)R16, SO2R17, NR13R14, and NR12SO2R6;
• R8 is selected from H, OR15, NR13R14, C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl;
• R9 is selected from C1-C4 alkyl and C(O)-alkyl;
• R10 and R11 are the same or different and independently selected from H, C1-C4 alkyl, and —C(O)-alkyl;
• R12 is selected from H, C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, C4-C9 heterocycloalkylalkyl, aryl, mixed aryl and non-aryl polycycle, heteroaryl, arylalkyl, and heteroarylalkyl;
• R13 and R14 are the same or different and independently selected from H, C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, amino acyl, or R13 and R14 together with the nitrogen to which they are bound are C4-C9 heterocycloalkyl, heteroaryl, polyheteroaryl, non-aromatic polyheterocycle or mixed aryl and non-aryl polyheterocycle;
• R15 is selected from H, C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl and (CH2)mZR12;
• R16 is selected from C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, polyheteroaryl, arylalkyl, heteroarylalkyl and (CH2)mZR12;
• R17 is selected from C1-C6 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, aromatic polycycle, heteroaryl, arylalkyl, heteroarylalkyl, polyheteroaryl and NR13R14;
• m is an integer selected from 0 to 6;
• and
• Z is selected from O, NR13, S and S(O);
• or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.