Pharmaceutical composition for and method of treating leukemia
AssigneeUniversity of Arizona Foundation
InventorJames Berger Camden
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Abstract
Method of treating leukemia, inhibiting the growth or proliferation of leukemic cells or extending the life span of a animal having leukemia are disclosed. The methods comprise the step of treating the leukemia with an effective amount of a compound of the Formula I or a pharmaceutically acceptable salt or prodrug form thereof, wherein: X is hydrogen, halogen or alkyl of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; R is hydrogen or an alkyl group of from 1 to 8 carbon atoms, alkylcarbamyl; R2 is 4-thiazolyl or NHCOOR1; and R1 is an aliphatic hydrocarbon of less than 7 carbon atoms. A chemotherapeutic agent and/or potentiator can be used in conjunction with the compound of the Formula I.
Claims23
A method of treating leukemia susceptible to treatment in an animal comprising the step of administering to the animal a composition comprising a pharmaceutically acceptable carrier and a safe and effective amount of a cleavable, covalently bonded derivative of a compound of the Formula I:
- wherein:
- X is hydrogen or halogen;
- n is a positive integer of less than 4;
- Y is hydrogen, chloro, nitro, methyl, or ethyl;
- R is hydrogen, an alkyl group of from 1 to 8 carbon atoms, or alkylcarbamoyl wherein the alkyl group has from 3 to 6 carbon atoms;
- R2 is NHCOOR1;
- and
- R1 is an aliphatie hydrocarbon of less than 7 carbon atoms
- wherein the cleavable, covalently bonded derivative is an phosphate ester, dimethyiglycine ester, aminoalkylbenzyl ester, aminoalkyl eater or a carboxyalkyl ester derivative.
A method of inhibiting the growth or proliferation of leukemic cells in vitro, in vivo or ex viva comprising the step of treating said cells with an effective amount of a cleavable, covalently bonded derivative of a compound of the Formula I:
- wherein:
- X is hydrogen or halogen;
- n is a positive integer of less than 4;
- Y is hydrogen, chloro, nitro, methyl, or ethyl;
- R is hydrogen, an alkyl group of from 1 to 8 carbon atoms, or alkylcarbamoyl wherein the alkyl group has from 3 to 6 carbon atoms;
- R2 is NHCOOR1;
- and
- R1 is an aliphatic hydrocarbon of less than 7 carbon atoms
- wherein the cleavable, covalently bonded derivative is an phosphate ester, dimethylglycine ester, aminoalkylbenzyl ester, aminoalkyl ester or a carboxyalkyl ester derivative.
A method of extending the life span of an animal having leukemia comprising the step of administering to the animal a safe and effective amount of a cleavable, covalently bonded derivative of a compound of the Formula I:
- wherein:
- X is hydrogenor halogen;
- n is a positive integer of less than 4;
- Y is hydrogen, chloro, intro, methyl, or ethyl;
- R is hydrogen, an alkyl group of from 1 to 8 carbon atoms, or alkylcarbamoyl wherein the alkyl group has from 3 to 6 carbon atoms;
- R2 is NHCOOR1;
- and
- R1 is an aliphatic hydrocarbon of less than 7 carbon atoms;
- whereby the life span of the animal is extended beyond the expected life span of a comparable animal having a comparable degree of leukemia development nor being treated with a cleavable, covalently bonded derivative of a compound of the Formula I and
- wherein the cleavable, covalently bonded derivative is an phosphate ester, dimethylglycine ester, aminoalkylbenzyl ester, aminoalkyl ester or a carboxyalkyl ester derivative.
Dependencies are inferred from the claim text.