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AssigneeThe United States of America as represented by the Secretary of Health and Human Services
InventorsMiao-Kun Sun, Daniel L. Alkon, Wei-Qin Zhao
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The invention provides a method for modulating attentive cognition comprising administering a compound that alters intraneuronal carbonic anhydrase activity thereby affecting establishment of a theta rhythm. The metabolic pathway of the compound preferably involves bicarbonate-mediated GABAergic depolarization. The term “attentive cognition” is meant to encompass memory formation, learning, spatial memory, and attention. The modulating may be stimulating, or the compound may have the multiple effects of inhibiting intraneuronal carbonic anhydrase activity, establishment of a theta rhythm, and memory acquisition. The invention further provides a method of modulating memory and attention comprising switching theta rhythm on and off, the switching comprising potentiating or inhibiting intraneuronal carbonic anhydrase activity.
A method of suppressing or enhancing attentive cognition in a mammal in need thereof comprising administering to the mammal a compound that modulates carbonic anhydrase activity in the brain in an amount sufficient to suppress or enhance attentive cognition.
A method of improving attentive cognition in a patient in need thereof comprising administering to the patient a compound that stimulates carbonic anhydrase activity in the brain in an amount sufficient to improve attentive cognition.
A method for treating a neurological disease or disorder in a mammal comprising administering to the mammal a stimulator of brain carbonic anhydrase activity in an amount effective to improve attentive cognition.
A method of stimulating synaptic transformation of inhibitory postsynaptic potentials into excitatory postsynaptic potentials in GABAergic synapses in a mammalian brain, comprising administering to the brain an activator of intraneuronal carbonic anhydrase activity, thereby stimulating the synaptic transformation in the synapses.
A method of blocking synaptic transformation of inhibitory postsynaptic potentials into excitatory postsynaptic potentials in GABAergic synapses in a mammalian brain, comprising determining a need for blocking, and administering to the brain an inhibitor of intraneuronal carbonic anhydrase activity, thereby blocking the synaptic transformation in the synapses.
Dependencies are inferred from the claim text.