Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals

A composition, comprising one or more compounds of formula I

• in which
• X, R1, R2, R3 are, independently of one another, NR6R7, CH2-pyridyl, or (CH2)n-phenyl, where n can be 0-6 and the phenyl radical can be substituted up to two times by F, Cl, Br, CF3, NH2, CN, OCF3, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, COO(C1-C6)-alkyl, COO(C3-C6)-cycloalkyl, CONH2, CONH(C1-C6)alkyl, or CON[(C1-C6)alkyl]2;
• (C1-C8)-alkyl, pyrrolidinyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, morpholinyl, tetrahydropyridinyl, tetrahydroquinolinyl, or tetrahydroisoquinolinyl, with each ring being unsubstituted or substituted by phenyl, (C1-C6)-alkyl-phenyl, —OH, (C1-C8)-alkyl, (C1-C6)-alkyl-OH, O-phenyl, S-phenyl, (CO)—(C1-C6)-alkyl, or (CO)-phenyl, where the phenyl substituent is unsubstituted or substituted up to two times by F, Cl, Br, OH, CF3, CN, OCF3, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, SO—(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, COOH, COO(C1-C6)alkyl, COO(C3-C6)cycloalkyl, CONH2, CONH(C1-C6)alkyl, CON[(C1-C6)alkyl]2, CONH(C3-C6)cycloalkyl, NH2, NH—CO—(C1-C6)-alkyl, or NH—CO-phenyl;
• R6 and R7 are, independently of one another, H, (C1-C6)-alkyl, (C1-C6)-alkyl-O—(C1-C6)-alkyl, O—(C1-C6)-alkyl, (C3-C6)-cycloalkyl, CO—(C1-C6)-alkyl, (C1-C6)-alkyl-NH—C(O)—(C1-C6)-alkyl, (C1-C6)-alkyl-NH—(C1-C6)-alkyl, (C1-C6)-alkyl-N-[(C1-C6)-alkyl]2, (C1-C6)-alkyl-O-phenyl, CHO, CO-phenyl, or
• (CH2)n—Ar, where n can be 0-6, and Ar can be equal to phenyl, biphenylyl, 1- or 2-naphthyl, 1- or 2-tetrahydrofuranyl, 2-, 3- or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furyl, 2-, 4- or 5-thiazolyl, 2-, 4- or 5-oxazolyl, 1-pyrazolyl, 3-, 4- or 5-isoxazolyl, (C3-C5)-cycloalkyl, piperdinyl, pyrrolidinyl, oxopyridyl, 2- or 3-pyrrolyl, 2- or 3-pyridazinyl, 2-, 4- or 5-pyrimidinyl, 2-pyrazinyl, 2-(1,3,5-triazinyl), 2-, 3- or 4-morpholinyl, 2- or 5-benzimidazolyl, 2-benzothiazolyl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, tetrazol-5-yl, indol-3-yl, indol-5-yl or N-methylimidazol-2-, -4- or -5-yl and Ar can be substituted up to two times by F, Cl, Br, OH, CF3, NO2, CN, OCF3, O—CH2—O, O—(C1-C6)-allyl, S—(C1-C6)-alkyl, SO—(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, COOH, COO(C1-C6)alkyl, COO(C3-C6)cycloalkyl, CONH2, CONH(C1-C6)alkyl, CON[(C1-C6)alkyl]2, CONH(C3-C6)cycloalkyl, NH2, NH—CO—(C1-C6)-alkyl, NH—CO-phenyl, pyrrolidin-1-yl, morpholin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-methylpiperazin-1-yl, (CH2)n-phenyl, O—(CH2)n-phenyl, S—(CH2)n-phenyl, or SO2—(CH2)n-phenyl, where n=0-3;
• or a physiologically acceptable salt thereof, and one or more lipid-lowering agents.