Methods and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists

A method of preventing or managing gastro-esophageal reflux disease in a patient in need thereof, which comprises administering a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer and a therapeutically effective amount of at least one of a proton pump inhibitor, an H2 receptor antagonist, or an optically pure stereoisomer or an active metabolite thereof, or a pharmaceutically acceptable salt thereof.