Indane or dihydroindole derivatives

A substituted indane or dihydroindole compound of Formula I

• Y is a hydrocarbon group completing an indane ring, a group NR1 completing a dihydroindole ring, or a group N completing a dihydroindole ring linked via the 1-position;
• W is a bond, and n+m is 1, 2, 3, 4, 5, or 6;
• W is CO, SO, or SO2, n is 2, 3, 4, or 5 and m is 0, 1, 2, or 3, provided that n+m is not more than 6;
• or
• W is O, S, n is 2, 3, 4, or 5, and m is 0, 1, 2, or 3, provided that n+m is not more than 6, and provided that if Y is N completing a dihydroindole ring attached via the 1-position then m is 2, or 3;
• and if Y is NR1 completing a dihydroindole ring linked via the 2-position then m is 1, 2, or 3;
• X is CH or COH;
• R1 is
• hydrogen, C1-6-alk(en/yn)yl, C3-8 cycloalk(en)yl, C3-8cycloalk(en)yl-C1-6-alk(en/yn)yl, aryl heteroaryl, aryl-C1-6-alkyl, heteroaryl-C1-6alkyl, acyl, thioacyl, C1-6alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl, or heteroarylsulfonyl;
• R15VCO— wherein V is O or S and R15 is C1-6-alk(en/yn)yl, C3-8cycloalk(en)yl, C3-8cycloalk(en)yl-C1-6-alk(en/yn)yl, aryl, or heteroaryl;
• or
• a group R16R17NCO— or R16R17NCS— wherein R16 and R17 are independently hydrogen, C1-6alk(en)/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, heteroaryl, or aryl, or R16 and R17 together with the N-atom to which they are linked, form a pyrrolidinyl, piperidinyl or perhydroazepin group;
• and
• R2-R5 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6 alkoxy, C1-6-alkylthio, hydroxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alkylcarbonyl, phenylcarbonyl, halogen substituted phenylcarbonyl, trifluoromethyl, trifluoromethylsulfonyloxy and C1-6 alkylsulfonyl;
• R6-R9 and R11-R12 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6 -alkoxy, C1-6-alkylthio, hydroxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6 alk(en/yn)yl, aryl, heteroaryl, phenylcarbonyl, halogen substituted phenylcarbonyl, trifluoromethyl, or C1-6 alkylsulfonyl, or two adjacent groups taken from R6-R9 may together form a methylenedioxy group;
• R10 is as defined for R1 above;
• or a pharmaceutical acceptable acid addition salt thereof.