Cyclized amide derivatives

A compound having formula (I):

• and pharmaceutically acceptable salts thereof, wherein:
• A and B are independently E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl;
• wherein 1 or 2 hydrogen atoms in said alkyl, alkenyl or alkynyl are optionally and independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl;
• and wherein 1 to 2 of the —CH2— groups in said alkyl groups is optionally and independently replaced by —O—, —S—, —S(O)—, —S(O)2—, or —N(R3)—;
• and wherein 1 or 2 ═CH— or —CH═ group, if present, in said alkenyl, or alkynyl groups is optionally replaced by ═N—, —N═;
• or, B is hydrogen;
• wherein R3 is selected from hydrogen, (C1-C4)-straight or branched alkyl, (C3-C4)-straight or branched alkenyl or alkynyl, or (C1-C4) bridging alkyl, wherein a bridge is formed between the nitrogen atom to which said R3 is bound and any carbon atom of said alkyl to form a ring, and wherein said ring is optionally benzofused;
• wherein E is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S;
• and wherein no more than 4 ring atoms are selected from N, O or S;
• wherein 1 to 4 hydrogen atoms in E are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O—[(C1-C6)-straight or branched alkyl], O—[(C3-C6)-straight or branched alkenyl], (CH2)n—N(R4) (R5), (CH2)n—NH(R4)—(CH2)n—Z, (CH2)n—O-Z, S—(CH2)n-Z, CH═CH-Z, 1,2-methylenedioxy, C(O)OH, C(O)O—[(C1-C6)-straight or branched alkyl],O C(O)O—(CH2)n-Z or C(O)—N(R4) (R5);
• wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S;
• wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z;
• each n is independently 0 to 4;
• each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S;
• and wherein no more than 4 ring atoms are selected from N, O or S;
• wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, O—(C1-C3)-straight or branched alkyl, C(O)O-[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or N-[(C1-C3)-straight or branched alkyl]2;
• J is selected from H, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, or cyclohexylmethyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E;
• wherein J is optionally substituted with up to 3 substituents selected from halogen, OH, O—(C1-C6)-alkyl, O—(CH2)n-Z, NO2, C(O)OH, C(O) —O—(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)n-Z;
• K, when present, is J;
• K1 and R1, taken together with the nitrogen atom and the —C(O)— group, form a monoazine ring, wherein 1 to 4 hydrogen atoms in said heterocyclic ring are optionally and independently replaced with (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, oxo, hydroxyl or Z;
• and wherein any —CH2— group said heterocyclic ring is optionally and independently replaced by —O—, —S—, —S(O)—, —S(O2)—, or —N(R3)—;
• and wherein said heterocyclic ring is optionally fused with
• G, when present, is —S(O)2—, —C(O)—, —S(O)2—Y—, —C(O)—Y—, —C(O)—C(O)—, or
• Y is oxygen, or N(R6);
• wherein R6 is hydrogen, E, (C1-C6)-straight or branched alkyl, (C3-C6)-straight or branched alkenyl or alkynyl;
• or wherein R and D are taken together with the atoms to which they are bound to form a 5 to 7 membered ring system wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from O, S, N, NH, SO, or SO2;
• and wherein said ring is optionally benzofused;
• D is an aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5-7 ring atoms independently selected from C, N, O or S, and wherein no more than 4 ring atoms are selected from N, O or S;
• m is 0 to 3;
• and
• x is 0 or 1.