Anticoagulant agents

A compound having the Formula I

• X—C(O)—Y—G—R I
• wherein
• X—C(O)— is D-homoprolinyl,
• Rm—(CH2)g—NH—CH2—C(O)—,
• in which
• Rd is carboxy or methylsulfonyl;
• Re is NHRC, NHCORC or NHCOORC;
• in which
• RC is (C1—C10)alkyl, (C3-C8)cycloalkyl or a (C3—C8)cycloalkyl—(C1—C6)alkyl radical of 4-10 carbons;
• T is (C3—C8)cycloalkyl, (C1—C8)alkyl,
• a is 0, 1 or 2;
• and
• Q is —OH, (C1—C4)alkoxy, or —NH—A;
• A is hydrogen, (C1—C4)alkyl, R″SO2—, R″OC(O)—, R″C(O)—, RnC(O)— or —(CH2)g-Rm;
• g is 1, 2, or 3;
• B is hydrogen or (C1—C4)alkyl;
• R′ is hydrogen or (C1—C4)alkyl;
• R″ is (C1—C4)alkyl, (C1—C4)fluoroalkyl bearing one to five fluoros, —(CH2)d-Rm, or unsubstituted or substituted aryl, where aryl is phenyl, naphthyl, a 5- or 6-membered unsubstituted or substituted aromatic heterocyclic ring, having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen, or a 9- or 10-membered unsubstituted or substituted fused bicyclic aromatic heterocyclic group having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen;
• provided that when A is R″SO2—, R″ is not (C1-C4)alkyl, (C1-C4)fluoroalkyl bearing one to five fluoros, —(CH2)d-Rm, or unsubstituted or substituted aryl, where aryl is phenyl or naphthyl;
• Rm is —COORb, —SO2(C1-C4 alkyl), —SO3H, —P(O)(ORb)2 or tetrazol-5-yl;
• Rn is —COORb or tetrazol-5-yl;
• each Rb is independently hydrogen or (C1-C4)alkyl;
• d is 1, 2, or 3;
• m is 0 or 2;
• n is 0, 1, or 2;
• and
• Z is hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy, hydroxy, halo or (C1—C4)alkylsulfonylamino;
• —Y—G— is
• —NRg—CH2—G—,
• or
• in which
• r is 0, 1 or 2;
• Rg is (C1-C6)alkyl, (C3-C8)cycloalkyl, or —(CH2)p-L-(CH2)q-T′;
• RP is (C1-C6)alkyl, (C3-C8)cycloalkyl, or —(CH2)p-L-(CH2)q-T′;
• where p is 0, 1 , 2, 3, or 4;
• L is a bond, —O—, —S—, or —NH—;
• q is 0, 1, 2 or 3;
• and T′ is (C1-C4)alkyl, (C3—C8)cycloalkyl, —COOH, —CONH2, or Ar, where Ar is unsubstituted or substituted aryl, where aryl is phenyl, naphthyl, a 5- or 6-membered unsubstituted or substituted aromatic heterocyclic ring, having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen, or a 9- or 10-membered unsubstituted or substituted fused bicyclic aromatic heterocyclic group having one or two heteroatoms which are the same or different and which are selected from sulfur, oxygen and nitrogen;
• Ry is —CH2—, —O—, —S—, or —NH—;
• and
• RZ is a bond or, when taken with Ry and the three adjoining carbon atoms, forms a saturated carbocyclic ring of 5-8 atoms, one atom of which may be —O—, —S—, or —NH—;
• —G—R is —C(O)—NH—(CH2)s—R, CH2—NH—(CH2)s—R, —CH2—NH—C(O)—R or —(CH2)t—O—R in which s is 1 or 2 and t is 1 , 2 or 3;
• and
• R is a 4-amidino-3-hydroxyphenyl group bearing 0, 1, 2 or 3 fluoro substituents;
• or a pharmaceutically acceptable salt thereof.