2-Substituted imidazo[1,2-A]pyridine derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• A, B, C, and D independently represent
• i) hydrogen, hydroxy, halogen, cyano, nitro,
• ii) C1-C6 alkyl optionally substituted independently with one, two, or three of Ra,
• iii) C2-C6 alkenyl optionally substituted independently with one, two, or three of Ra,
• iv) C2-C6 alkynyl optionally substituted independently with one, two, or three of Ra,
• v) C1-C6 alkoxy optionally substituted independently with one, two, or three of Ra,
• vi) alkylthio optionally substituted independently with one, two, or three of Ra,
• vii) alkylsulfinyl wherein the alkyl portion is optionally substituted independently with one, two, or three of Ra,
• viii) alkylsulfonyl wherein the alkyl portion is optionally substituted independently with one, two, or three of Ra,
• ix) —NR3R4, wherein R3 and R4 are independently hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, or C3-C7 cycloalkyl (C1-C6)alkyl, and
• x) —NR3R4, wherein R3 and R4 are joined to form a heterocyclic ring having from 3-7 members,
• where Ra is independently chosen at each occurrence from halogen, hydroxy, C1-C6 alkoxy, nitro, cyano, amino, or oxo,
• G is imidazolyl, imidazopyridinyl, imidazopyrazinyl, or benzimidazolyl, each of which is optionally substituted with up to three groups independently selected from:
• i) halogen, halo(C1-C6)alkyl, hydroxy, nitro, cyano,
• ii) arylalkyl, wherein the aryl portion of the arylalkyl moiety is optionally substituted with one, two, or three groups which are independently chosen from halogen, nitro, cyano, hydroxy, halo(C1-C6)alkyl, amino, mono- and di-alkyl(C1-C6)amino,
• iii) —NR5R6 wherein R5 and R6 are the same or different and independently represent hydrogen, alkoxyalkyl, or C1-C6alkyl substituted with —(CH2)m—NR7R8, wherein m is 0 or an integer of from 1 to 6 and R7, and R8 are the same or different and represent hydrogen, C1-C6 alkyl, C3-C7cycloalkyl, or C3-C7 cycloalkyl(C1-C6)alkyl,
• iv) C1-C6 alkyl and C1-C6 alkoxy, each of which is optionally substituted with one or two of Rb, and
• v) heterocycloalkyl optionally substituted with up to three groups which are independently chosen from halogen, hydroxy, nitro, cyano, halo(C1-C6)alkyl, C1-C6alkyl, (C1-C6)alkoxy, (C1-C6)alkoxy (C1-C6)alkyl, (C1-C6)alkoxy (C1-C6)alkoxy, (C3-C7)cycloalkyl (C1-C6)alkoxy, cycloalkyl(C1-C6)alkyl, hydroxy(C1-C6)alkyl, hydroxy(C1-C6)alkoxy, amino(C1-C6)alkyl, and phenyl;
• W is phenyl or pyridyl, each of which is optionally substituted with one, two, or three groups which are independently chosen from
• i) halogen, nitro, cyano, hydroxy, halo(C1-C6)alkyl, amino, mono- and di-(C1-C6)alkylamino,
• ii) C1-C6 alkyl and C1-C6 alkoxy, each of which is optionally substituted with one or two of Rc,
• Rb and Rc are independently chosen at each occurrence from:
• i) hydroxy, C1-C6alkoxy, C3-C7cycloalkyl, C3-C7cycloalkyl(C1-C6)alkoxy, heterocycloalkyl,
• ii) —(CH2)x—NR9R10, wherein x is 0 or an integer of 1 to 6, and R9 and R10 are the same or different and represent hydrogen, C1-C6 alkyl, C3-C7cycloalkyl, or C3-C7 cycloalkyl(C1-C6)alkyl, and
• iii) —NR9R10, where R9 and R10 are joined to form a heterocyclic ring having from 3-7 members;
• and
• X is O, NH, N(C1-C6 alkyl), S, SO2, or (CH2)n, wherein n is 1, 2, 3, or 4.