Imidazo-containing heterocyclic compounds, their compositions and uses
AssigneeThe Procter & Gamble Company
InventorsSong Liu, David Edward Portlock, Schwe Fang Pong
Life of this patent
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Abstract
The subject invention involves compounds having the structure: wherein each R1 is independently alkyl, aryl, or heterocycle; each R2-R7 is independently hydrogen or other substituent; B is nil and n is 0-3, or B is ethenyl and n is 0-1; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.
Claims16
A compound, enatiomer, diasteriomer or pharmaceutically acceptable salt thereof, said compound having the formula:
- wherein each R1 is independently methyl, ethyl, vinyl, n-propyl, isopropyl, allyl, iso-propenyl, sec-butyl, cyclopropyl, cyclobutyl, or cyclopentyl;
- each R3 is independently hydrogen, fluoro, chloro, bromo, methyl, trifluoromethyl, dimethylamino, diethylamino, or dibutylamino, each R6 is independently hydrogen, alkylthio, or alkoxy.
A composition comprising:
- a) one or more compounds having the formula:
- wherein each R1 is independently methyl, ethyl, vinyl, n-propyl, iso-propyl, allyl, isopropenyl, sec-butyl, cyclopropyl, cyclobutyl, or cyclopentyl;
- each R3 is independently hydrogen, fluoro, chloro, bromo, methyl, trifluoromethyl, dimethylamino, diethylamino, or dibutylamino;
- each R6 is independently hydrogen, alkylthio, or alkoxy;
- and
- b) one or more pharmaceutically acceptable excipients or carriers.
A method for treating or preventing congestive heart failure or hypotension, said method comprising the steps of administering to a human or lower animal in need thereof, an effective amount of a compound having the formula:
- wherein each R1 is independently methyl, ethyl, vinyl, n-propyl, isopropyl, allyl, iso-propenyl, sec-butyl, cyclopropyl, cyclobutyl, or cyclopentyl;
- each R3 is independently hydrogen, fluoro, chloro, bromo, methyl, trifluoromethyl, dimethylamino, diethylamino, or dibutylamino;
- each R6 is independently hydrogen, alkylthio, or alkoxy.
A method for treating or preventing cardiac arrhythmia or cardiac reperfusion injury caused by cellular protein transport, said method comprising the steps of administering to a human or lower animal in need thereof, an effective amount of a compound having the formula:
- wherein each R1 is independently methyl, ethyl, vinyl, n-propyl, isopropyl, allyl, iso-propenyl, sec-butyl, cyclopropyl, cyclobutyl, or cyclopentyl;
- each R3 is independently hydrogen, fluoro, chloro, bromo, methyl, trifluoromethyl, dimethylamino, diethylamino, or dibutylamino;
- each R6 is independently hydrogen, alkylthio, or alkoxy.
Dependencies are inferred from the claim text.