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US 6,552,027 B2Granted
Quinazolines for treating brain tumor
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Rama Krishna Narla, Xing-Ping Liu
Life of this patent
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Abstract
Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.
Claims2
A method comprising contacting brain tumor cells with a brain tumor cell apoptosis inducing amount of a compound of the formula:
A method comprising contacting brain tumor cells with a brain tumor cell metastases preventing amount of a compound of the formula:
Dependencies are inferred from the claim text.