US 6,552,020 B1 · Compositions including antibiotics and methods for using same

Abstract

Compositions including a quinolone component, such as ofloxacin, having fungistatic activity in the compositions, present in an amount effective as an antibiotic when the composition is placed in a mammalian eye, a NSAID component present in an amount to reduce inflammation or pain when the composition is placed in the eye, and a carrier component in an amount effective to act as a carrier for the quinolone component and NSAID component are provided. Methods of using the present compositions, for example, to resolve microbial infections and/or to reduce inflammation and/or pain in a mammalian eye are included within the scope of the present invention. Methods for treating corneal injuries are also included. In addition, methods for treating ocular infections, for example, corneal infections, are included.

Claims34

Dependent claims

A method for treating an ocular infection comprising:

administering to a mammalian eye having an infection caused by one or more pathogens a therapeutically effective amount of a composition comprising quinolone component in an amount effective as an antibiotic in the mammalian eye and a NSAID component in an amount effective to reduce the time needed to eliminate the infection relative to identically administering a similar composition without the NSAID component, the composition being free of other components effective as preservatives, the composition being sufficiently self-preserved so as to pass the United States Preservative Efficacy Test.

Dependencies are inferred from the claim text.

Facts

Application

09/624,129Filed 24 Jul 2000 · continuation in part

Priority

30 Jul 1999

Granted

22 Apr 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/535
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with at least one nitrogen and one oxygen as the…
A61K 31/5365
Having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines: ortho- or peri-condensed with…

Compositions including antibiotics and methods for using same

Life of this patent

Compositions including antibiotics and methods for using same

Life of this patent

Abstract

Claims34