Pyrazole derivatives
AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsAkio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito
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AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsAkio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito
Estimating the term…
The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.
A compound represented by formula (I) or a salt thereof;
Dependencies are inferred from the claim text.