Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Veteran Affairs
InventorsEyal Raz, Richard Kornbluth, Antonio Catanzaro, Tomoko Hayashi, Dennis Carson
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Abstract
The present invention features methods for treatment or prevention of infection by intracellular pathogens (e.g., Mycobacterium species) by administration of an immunomodulatory nucleic acid molecule. In one embodiment, immunomodulatory nucleic acid molecule are administered in combination with another anti-pathogenic agent to provide a synergistic anti-pathogenic effect.
Claims43
A method for treating mycobacterial infection in a subject, the method comprising:
- administering to a subject an immunomodulatory nucleic acid molecule in an amount effective to inhibit intracellular replication of the mycobacterium, wherein the immunomodulatory nucleic acid comprises an immunostimulatory sequence comprising 5′ CpG 3′;
- and
- administering to the subject an anti-pathogenic agent in an amount effective to decrease or inhibit growth of the mycobacterium,
- thereby treating the infection.
A method for treating a mycobacterial infection in a subject, the method comprising:
- administering to a subject multiple doses of an immunomodulatory nucleic acid molecule in an amount effective to inhibit replication of a Mycobacterium bacterium, thereby treating the mycobacterial infection in the subject, wherein the immunomodulatory nucleic acid comprises an immunostimulatory sequence comprising 5′ CpG 3′.
A method for inducing in a subject an immune response against a Mycobacterium bacterium, the method comprising:
- administering to a subject multiple doses of an immunomodulatory nucleic acid molecule in an amount effective to elicit an immune response against a Mycobacterium bacterium, wherein the immunomodulatory nucleic acid comprises an immunostimulatory sequence comprising 5′ CpG 3′;
- wherein said administering results in induction of an immune response effective to protect the subject against onset of disease or to decrease severity of symptoms of disease caused by infection by the Mycobacterium bacterium.
A method treating a mycobacterial infection, the method comprising:
- administering to a subject an amount of an immunomodulatory nucleic acid molecule in an amount effective to inhibit intracellular replication of a Mycobacterium bacterium in the subject, wherein the immunomodulatory nucleic acid comprises an immunostimulatory sequence comprising 5′ CpG 3′;
- and
- administering to the subject an antimicrobial agent in an amount effective to decrease or inhibit growth of the Mycobacterium bacterium;
- wherein said administering is effective to decrease severity of symptoms of disease caused by the Mycobacterium bacterium.
Dependencies are inferred from the claim text.