Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
AssigneeMcGill University
InventorsOrest W. Blaschuk, Barbara J. Gour
Life of this patent
Estimating the term…
Abstract
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or mimetic of a β-catenin HAV motif; or (c) an antibody or antigen-binding fragment thereof that specifically binds to a β-catenin HAV motif. Methods for using such modulating agents for inhibiting cadherin-mediated cell adhesion in a variety of contexts are also provided.
Claims23
A modulating agent for inhibiting an interaction between α-catenin and β-catenin, comprising
- the amino acid sequence KHAVV (SEQ ID NO:1).
A modulating agent for inhibiting an interaction between α-catenin and β-catenin, comprising
- a β-catenin HAV motif
- wherein the modulating agent is associated with an internalization moiety.
Dependencies are inferred from the claim text.