US 6,551,823 B2 · EBV-infected stomach cancer cell line

Abstract

An EBV strain infecting epithelial cells and a stomach cancer cell line cancerated by EBV are established to clarify the mechanism of canceration of epithelial cells into stomach cancer by EBV and to develop a chemotherapeutic agent for stomach cancer cancerated by EBV. Further, a stomach cancer cell line stably producing EBV-related antigens is established to develop a diagnostic drug for stomach cancer cancerated by EBV. According to the present invention, GTC-4 cell line was established through culture of stomach cancer tissues. GTC-4 produced the EBV strain infecting epithelial cells and simultaneously produced EBV-related antigens stably in the supernatant.

Claims5

Dependent claims

A method of producing an EBV antigen comprising, culturing GTC-4 cells deposited as accession number ECACC99012705 and expressing the antigen.

Dependencies are inferred from the claim text.

Facts

Application

09/882,034Filed 18 Jun 2001 · continuation in part

Priority

JP 11-275314 Feb 1999

Published

US 2001/0044148 A122 Nov 2001

Granted

22 Apr 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C12N 7/00
Viruses
A61P 35/00
Antineoplastic agents
C12N 2710/16611
Herpesviridae: simplexvirus, e.g. human herpesvirus 1, 2
C12N 2710/16622
Simplexvirus, e.g. human herpesvirus 1, 2: new viral proteins or individual genes, new structural or functional aspects of known viral proteins or…

EBV-infected stomach cancer cell line

Life of this patent

EBV-infected stomach cancer cell line

Life of this patent

Abstract

Claims5