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AssigneeThe Trustees of Columbia University in the City of New York
InventorsEric R. Kandel, Bina Santoro, Dusan Bartsch, Steven Siegelbaum, Gareth Tibbs, Seth Grant
Estimating the term…
The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition. Finally, the present invention provides an antibody which specifically reacts with BCNG protein.
An isolated nucleic acid that encodes a cyclic nucleotide-gated ion channel protein and that specifically hybridizes with SEQ ID NO:1, or the complement thereof, under conditions comprising two thirty-minute washes at. 65° C. in a solution comprising 0.2×SSC and 0.1% SDS.
An isolated nucleic acid having a sequence encoding a brain cyclic nucleotide gate ion channel protein which sequence is shown in SEQ ID NO:1.
A composition comprising a nucleic acid having a sequence encoding a BCNG protein which sequence is shown in SEQ. ID. No.:1 and a carrier.
Dependencies are inferred from the claim text.