Preparing enzyme-containing polymers by reacting an enzyme in organic solution with crosslinking compounds
AssigneeBASF SE
InventorRainer Stürmer
Life of this patent
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Abstract
Enzyme-containing polymers are prepared by an anhydrous process of direct reaction of an enzyme in organic solution with crosslinking organic compounds having terminal reactive groups. In a first step, the enzyme is reacted in an organic solvent with a bifunctional monomer such as p-phenylene diisocyanate, 4-methyl-m-phenylene diisocyanate or 4,4′-methylenebisphenyl diisocyanate, and in a second step a bifunctional amine such as N-phenylethylenediamine, 1,6-diaminohexane, N,N′-diethyl-ethylenediamine or 1,4-diaminobutane is added. The enzyme-containing polymers are used as catalysts in chemical reactions such as acylation or enantioselective acylation of alcohols.
Claims14
A process for preparing an enzyme-containing polymer, which comprises, in a first step, reacting an enzyme in an organic solvent with an at least bifunctional monomer having the formula
- R1(X)s(Y)t
- where
- R1 is an alkane, alkene, cycloalkane, cycloalkene, arene, arylalkane, diaryl ether, diaryl thioether or diarylamine group, and wherein if R1 is cyclic it is optionally substituted by from one to four C1-C4-alkyl, C1-C4-haloalkyl and/or halogen radicals,
- s has a value of from 0 to 5,
- t has a value of from 0 to 5, and
- s+t has a value of from 2 to 5, and
- X is isocyanate,
- Y is isothiocyanate, or
- X═Y is —COR3, and
- R3 is a leaving group which can be displaced by the amino, hydroxyl or mercapto functionality of the enzyme,
- and in a second step, adding an at least bifunctional amine or a mixture of at least bifunctional amines.
Dependencies are inferred from the claim text.