Nucleic acid encoding urate transporter and methods of use thereof
AssigneeMount Sinai School of Medicine
InventorsRuth G. Abramson, Edgar Leal-Pinto, Michael Lipkowitz
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Abstract
The present invention provides an isolated nucleic acid encoding a urate transporter, vectors comprising the nucleic acid, host cells comprising the nucleic acid, and host cells comprising the vectors. Compositions comprising the vectors and a carrier are also provided. In another embodiment, the present invention provides isolated and substantially purified urate transporter. Proteoliposomes containing substantially purified urate transporter are also provided, as well as compositions comprising the urate transporter and a carrier. The present invention further provides methods of making a urate transporter, and methods of identifying agents that inhibit or agonize the transporter.
Claims14
An isolated nucleic acid encoding a urate transporter comprising the nucleotide sequence of SEQ ID NO:3.
An isolated nucleic acid comprising the nucleotide sequence from nucleotide 1 to nucleotide 969 of SEQ ID NO:3.
An isolated nucleic acid comprising a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.