Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
AssigneeGenome Therapeutics Corporation
InventorsMarc J. Rubenfield, Jork Nolling, Craig Deloughery, David Bush
Life of this patent
Estimating the term…
Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Claims26
An isolated nucleic acid comprising a nucleotide sequence encoding a P. aeruginosa polypeptide selected from the group consisting of SEQ ID NO:
- 17411, SEQ ID NO:
- 17456, SEQ ID NO:
- 18830, SEQ ID NO:
- 21016, SEQ ID NO:
- 21380, SEQ ID NO:
- 22234, SEQ ID NO:
- 24200, SEQ ID NO:
- 27183, SEQ ID NO:
- 27280, and SEQ ID NO:
- 32329.
An isolated nucleic acid comprising a nucleotide sequence encoding a P. aeruginosa polypeptide, said nucleic acid selected from the group consisting of SEQ ID NO:
- 840, SEQ ID NO:
- 885, SEQ ID NO:
- 2259, SEQ ID NO:
- 4445, SEQ ID NO:
- 4809, SEQ ID NO:
- 5663, SEQ ID NO:
- 7629, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758.
A probe comprising a nucleotide sequence of at least 30 nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 4445, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758.
An isolated nucleic acid or the complement thereof comprising a nucleotide sequence of at least 40 nucleotides in length selected from the group consisting of SEQ ID NO:
- 4445, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758, wherein the sequence is hybridizable under conditions of high stringency to a nucleic acid having a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 4445, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758, or the complement thereof.
An isolated nucleic acid comprising a nucleotide sequence encoding a P. aeruginosa polypeptide selected from the group consisting of SEQ ID NO:
- 17456, SEQ ID NO:
- 18830, SEQ ID NO:
- 21016, SEQ ID NO:
- 21380, SEQ ID NO:
- 22234, SEQ ID NO:
- 27183, SEQ ID NO:
- 27280, and SEQ ID NO:
- 32329.
An isolated nucleic acid comprising a nucleotide sequence with at least 80% sequence identity to a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 885, SEQ ID NO:
- 2259, SEQ ID NO:
- 4445, SEQ ID NO:
- 4809, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758, and wherein said isolated nucleic acid encodes a P. aeruginosa polypeptide selected from the group consisting of SEQ ID NO:
- 17456, SEQ ID NO:
- 18830, SEQ ID NO:
- 21016, SEQ ID NO:
- 21380, SEQ ID NO:
- 22234, SEQ ID NO:
- 27183, SEQ ID NO:
- 27280, and SEQ ID NO:
- 32329, respectively.
An isolated nucleic acid comprising a nucleotide sequence with at least 90% sequence identity to a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 885, SEQ ID NO:
- 2259, SEQ ID NO:
- 4445, SEQ ID NO:
- 4809, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758 and wherein said isolated nucleic acid encodes a P. aeruginosa polypeptide selected from the group consisting of SEQ ID NO:
- 17456, SEQ ID NO:
- 18830, SEQ ID NO:
- 21016, SEQ ID NO:
- 21380, SEQ ID NO:
- 22234, SEQ ID NO:
- 27183, SEQ ID NO:
- 27280, and SEQ ID NO:
- 32329.
An isolated nucleic acid comprising a nucleotide sequence encoding a P. aeruginosa polypeptide, said nucleic acid selected from the group consisting of SEQ ID NO:
- 885, SEQ ID NO:
- 2259, SEQ ID NO:
- 4445, SEQ ID NO:
- 4809, SEQ ID NO:
- 5663, SEQ ID NO:
- 10612, SEQ ID NO:
- 10709, and SEQ ID NO:
- 15758.
Dependencies are inferred from the claim text.