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US 6,551,785 B2Granted
Diagnostics for bacterial meningitus
AssigneeInterleukin Genetics, Inc.
InventorsFrancesco Saverio di Giovine, Gordon W. Duff
Life of this patent
Estimating the term…
Abstract
Methods and kits for detecting polymorphism that are predictive of a subject's susceptibility to developing sepsis are described.
Claims8
A method for predicting the severity with which a subject is likely to develop bacterial meningitis, said method comprising the steps of:
- a) obtaining a nucleic acid sample from the subject;
- and
- b) detecting at least one allele in linkage disequilibrium with IL-1B (−511) allele 2 in said sample;
- wherein said at least one allele is located in the promoter of the IL-1B gene and wherein detection that the sample is homozygous for said at least one allele indicates that the subject is likely to develop severe bacterial meningitis.
1 more element
A method for predicting the severity with which a subject is likely to develop bacterial meningitis, said method comprising the steps of:
- a) obtaining a nucleic acid sample from the subject;
- and
- b) detecting IL-1B (−511) allele 2 in said sample;
- wherein detection that the sample is homozygous for said allele indicates that the subject is likely to develop severe bacterial meningitis.
1 more element
Dependencies are inferred from the claim text.