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AssigneesBoard of Regents, The University of Texas System, The Regents of the University of California, Geron Corporation
InventorsMichael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
Estimating the term…
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
Method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a mammalian cell comprising the steps of:
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