Taste masking coating composition
AssigneeBristol-Myers Squibb Company
InventorsMichael Corbo, Jatin Desai, Mahesh Patell, Ronald Warrick
Life of this patent
Estimating the term…
Abstract
There is provided a coating composition that masks the undesirable taste of a pharmaceutically active ingredient, i.e. drug or medicine, that is consumed orally. The coating composition has polyvinyl acetate, and a dimethylaminoethyl methacrylate and neutral methacrylic acid ester. Optionally, an alkaline modifier may be included in the coating composition to enhance release of the active ingredient.
Claims42
A coating composition for masking the taste of a drug ingredient or medicine and for providing rapid and substantially complete release of the drug ingredient or medicine in the stomach when the drug ingredient or medicine is coated with the composition, comprising a taste masking blend of:
- (a) polyvinyl acetate;
- (b) dimethylaminoethyl methacrylate and neutral methacrylic acid ester;
- and
- (c) an alkaline modifier;
- the alkaline modifier being present in the coating composition, as a component thereof, in an amount sufficient to increase the coating composition's dissolution rate in the stomach as compared to a like composition that does not contain the alkaline modifier, said drug ingredient or medicine, when coated with the coating composition and orally ingested, having its taste masked in the mouth then being rapidly and substantially completely released in the stomach.
A medicament comprising:
- an effective amount of a drug ingredient having an unpleasant taste;
- and
- a coating composition for masking the taste of the drug ingredient and enhancing release of the drug ingredient in the stomach, the drug ingredient being coated by the coating composition, the coating composition comprising a taste masking blend of:
- (a) polyvinyl acetate;
- (b) dimethylaminoethyl methacrylate and neutral methacrylic acid ester;
- and
- (c) an alkaline modifier;
- the alkaline modifier being present in the coating composition, as a component thereof, in an amount sufficient to increase the coating composition's dissolution rate in the stomach, as compared to a like coating composition that does not contain the alkaline modifier, the unpleasant taste of the drug ingredient being masked when the medicament is orally ingested, the drug thereafter being rapidly and substantially completely released in the stomach.
A medicament comprising:
- an effective amount of a drug ingredient having an unpleasant taste;
- and
- a coating composition for masking the taste of the drug ingredient and enhancing the release of the drug ingredient in the stomach, the drug ingredient being coated by the coating composition, the coating composition comprising a taste masking amount of a blend of:
- (a) polyvinyl acetate in an amount of about 3 wt. % to about 97 wt. % of the total weight of the composition;
- (b) dimethylaminoethyl methacrylate and neutral methacrylic acid ester in an amount of about 3 wt. % to about 97 wt. % of the total weight of the composition;
- (c) an alkaline modifier in an amount of about 0.2 wt. % to about 20 wt. % of the total weight of the composition;
- and
- (d) an additive selected from the group consisting of polyvinylpyrrolidone, 2-vinyl pyridine (V)/styrene (S) copolymer, ethyl cellulose, and mixtures thereof;
- the amount of the alkaline modifier being sufficient to increase the coating's dissolution rate in the stomach, as compared to a like medicament in which the drug ingredient is coated with a like coating composition that does not contain the alkaline modifier, the unpleasant taste of the drug ingredient being masked when the medicament is orally ingested, the drug ingredient thereafter being rapidly and substantially completely released in the stomach.
A medicament comprising:
- an effective amount of a drug ingredient;
- and
- a coating composition for masking the taste of the drug ingredient and enhancing the release of the drug ingredient in the stomach, the drug ingredient being coated by the coating composition, the coating composition comprising a taste masking blend of:
- (a) polyvinyl acetate in an amount of about 28 wt. % of the total weight of the composition;
- (b) dimethylaminoethyl methacrylate and neutral methacrylic acid ester in an amount of about 28 wt. % of the total weight of the composition;
- (c) ethyl cellulose in an amount of about 28 wt. % of the total weight of the composition;
- (d) talc in an amount of about 5 wt. % of the total weight of the composition;
- (e) other alkaline modifier in an amount of about 3 wt. % to about 11 wt. % of the total weight of the composition;
- the amount of the talc and other alkaline modifier being sufficient to increase the coating's dissolution rate in the stomach, as compared to a like medicament in which the drug ingredient is coated with a like coating composition except that it does not contain talc or said other alkaline modifier as a component thereof, the unpleasant taste of the drug ingredient being masked when the medicament is orally ingested, the drug ingredient thereafter being rapidly and substantially completely released in the stomach.
Method for increasing the release rate of an unpleasant tasting active in a chewable tablet containing same, the active being coated with a coating composition containing a taste masking blend of polyvinyl acetate and dimethylaminoethyl methacrylate and neutral methacrylic acid ester, comprising incorporating an alkaline modifier in the coating composition and adjusting the amount of the alkaline modifier that is incorporated so that the unpleasant taste of the active is masked when the tablet is chewed and the active is rapidly and substantially completely released in the stomach.
Dependencies are inferred from the claim text.