Antimalarial N,N′-substituted biguanides derived from hydroxylamines
AssigneeJacobus Pharmaceutical Company, Inc.
InventorsDavid P. Jacobus, Norman P. Jensen
Life of this patent
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Abstract
Compounds of the formulae are disclosed. A method of protecting subjects from infections caused by an organism of the group: Plasmodium sp., Mycobacterium sp., P. falciparum, M. avium complex, M. tuberculosis, M. kanasii and Pneumocystis carinii by administering to the subjects liable to infections, a prophylactically effective amount of a compound of the foregoing formulae; and a method of reducing the level of infection in subjects caused by the above-listed organism by administering to the subjects an infection reductively effective amount of a compound of the foregoing formulae are also disclosed.
Claims8
A method of protecting subjects from infections caused by an organism selected from the group consisting of:
- Plasmodium sp., Mycobacterium sp., and Pneumocystis carinii which comprises administering to a subject liable to infection by exposure to such organism, a composition comprising a prophylactically effective amount of a compound of the formula
- or a pharmaceutically acceptable salt thereof,
- wherein said composition does not cause testicular atrophy in male subjects.
A method of reducing the level of infection in a subject suffering therefrom caused by an organism selected from the group consisting of:
- Plasmodium sp., Mycobacterium sp., and Pneumocystis carinii which comprises administering to an infected subject, a composition comprising an infection reductively effective amount of a compound of the formula
- or a pharmaceutically acceptable salt thereof;
- wherein said composition does not cause testicular atrophy in male subjects.
A method of protecting subjects from infections caused by an organism selected from the group consisting of:
- Plasmodium sp., Mycobacterium sp., and Pneumocystis carinii which comprises administering to a subject liable to infection by exposure to such organism, a composition comprising a prophylactically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein said composition does not cause testicular atrophy in male subjects.
A method of reducing the level of infection in a subject suffering therefrom caused by an organism selected from the group consisting of:
- Plasmodium sp., Mycobacterium sp., and Pneumocystis carinii which comprises administering to an infected subject, a composition comprising an infection reductively effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein said composition does not cause testicular atrophy in male subjects.
Dependencies are inferred from the claim text.