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US 6,551,613 B1Granted
Dosage form comprising therapeutic formulation
AssigneeAlza Corporation
InventorsLiang-Chang Dong, Patrick S. L. Wong, Vincent Joseph Ferrari, Steven Espinal
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Abstract
A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.
Claims5
A process for providing a dosage form, said process comprising the following steps:
- (a) blending an osmopolymer, an osmagent and a hydroxypropylalkylcellulose to provide an osmotic composition;
- (b) blending a hydroxyalkylcellulose with a fluid to provide a granulating fluid;
- (c) spraying the granulating fluid onto the osmotic composition;
- (d) blending a drug and surfactant to form a liquid drug formulation wherein the liquid drug formulation is delivered at a sustained-release rate over an extended period of time:
- (e) adding the liquid drug formulation into a capsule;
- (f) adding the osmotic composition into the capsule;
- (g) closing the capsule;
- (h) inserting the capsule into a wall housing comprised of an injection-moldable composition having a closed bottom and an open mouth;
- and
- (i) crimping the wall to close the mouth while maintaining an orifice in the dosage form.
7 more elements
A process for providing a dosage form, wherein the process comprises the following steps:
- (a) formulating a liquid drug formulation comprising a drug and a pharmaceutically acceptable carrier;
- (b) formulating an expandable composition comprising a homopolymer and an osmotically effective solute;
- (c) adding the therapeutic composition to a capsule;
- (d) adding the expandable composition to the capsule;
- (e) coating the capsule with an injection-moldable composition to form a wall;
- and
- (f) providing an exit means in the wall in communication with the liquid drug formulation for releasing the liquid drug formulation at a sustained-release rate over an extended period of time.
4 more elements
Dependencies are inferred from the claim text.