Diesters or polyesters of naphthalene dicarboxylic acid as solubilizer/stabilizer for retinoids
AssigneeHaarmann & Reimer GmbH
InventorCraig A. Bonda
Life of this patent
Estimating the term…
Abstract
A topical composition for skin treatment comprising about 60.001% to 1% by weight of a retinoid solubilizer and/or stabilized with preferably about 0.1% to about 50% by weight of a diester or polyester of a naphthalene dicarboxylic acid having compound formula (I), (II), (III) or mixtures: wherein R1 is an alkyl group, straight chain or branched, having 1 to 22 carbon atoms; wherein each R1, same or different, is an alkyl group having 1 to 22 carbon atoms, a diol having the structure HO—R2—OH, or a polyglycol having the structure HO—R3—(—O—R2—)m—OH wherein R2 and R3, same or different, are each an alkylene group, straight chain or branched, having 1 to 6 carbon atoms, and wherein m and n are each 1 to about 100, or a mixture thereof.
Claims16
A composition comprising about 0.001% to about 1% of a retinoid, and about 0.1% by weight of a diester or polyester of naphthalene dicarboxylic acid selected from the group consisting of formula (I), formula (II), formula (III) and mixtures thereof:
- wherein each R1, same or different, is an alkyl group, straight chain or branched, having 1 to 22 carbon atoms;
- wherein each R1 of formula III, same or different, is selected from the group consisting of an alkyl group having 1 to 22 carbon atoms;
- a diol having the structure HO—R2—OH;
- and a polyglycol having the structure HO—R3—(—OOR2—)m—OH, wherein R2 and R3, same or different, are each an alkylene group, straight chain or branched, having 1 to 6 carbon atoms, and wherein m and n are each in the range of 1 to about 100, or a mixture thereof.
A method of delivering a retinoid topically to skin comprising mixing with the retinoid about 0.1% to 99.999% by weight to form a composition, wherein the percentage is based on the total weight of the composition, of a diester or polyester of a naphthalene dicarboxylic acid stabilizing compound selected from the group consisting of formula (I), formula (II), formula (III) and mixtures thereof:
- wherein R1 is an alkyl group, straight chain or branched, having 1 to 22 carbon atoms;
- wherein each R1, same or different, is selected from the group consisting of an alkyl group having 1 to 22 carbon atoms;
- a diol having the structure HO—R2—OH;
- and a polyglycol having the structure HO—R3—(—O—R2—)m—OH, wherein R2 and R3, same or different, are each an alkylene group, straight chain or branched, having 1 to 6 carbon atoms, and wherein m and n are each in the range of 1 to about 100, or a mixture thereof;
- and then applying the composition topically to skin.
Dependencies are inferred from the claim text.