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US 6,551,597 B1Granted
Vaccine compositions for human papillomavirus
AssigneePresident and Fellows of Harvard College
InventorsStephen Harrison, Xiaojiang Chen
Life of this patent
Estimating the term…
Abstract
Large quantities of soluble multimers of human papillomavirus L1 proteins can be produced in bacterial expression systems and used as therapeutic and diagnostic tools. L1 multimers can be used in immunogenic vaccine compositions, as diagnostic reagents, and as tools for mapping cell surface receptor interactions.
Claims9
A composition comprising:
- a multimer of a human papillomavirus L1 protein, comprising at least 10 human papillomavirus L1 protein monomers assembled into at least 2 pentamers, wherein the L1 protein does not include amino terminal residues 1-8;
- and a pharmacologically acceptable carrier.
Dependencies are inferred from the claim text.