Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
AssigneeMillennium Pharmaceuticals, Inc.
InventorsDouglas J. Ringler, Dominic Picarella, Walter Newman
Life of this patent
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Abstract
The invention relates to the treatment of individuals suffering from a disease associated with leukocyte recruitment to the gastrointestinal tract or other tissues as a result of binding of leukocytes to gut-associated endothelium expressing the molecule MAdCAM (such as inflammatory bowel disease), comprising administering to the individual an effective amount of an antibody which inhibits the binding of leukocytes to endothelial MAdCAM.
Claims22
A method for treating an individual having a disease associated with leukocyte recruitment to the gastrointestinal tract or other tissues as a result of binding of leukocytes to gut-associated endothelium expressing the molecule MAdCAM, comprising administering to the individual an effective amount of an antibody or antigen binding fragment thereof, said antibody or fragment having the epitopic specificity of the ACT-1 monoclonal antibody.
A method for treating inflammatory bowel disease in an individual comprising administering to the individual an effective amount of an antibody or antigen binding fragment thereof, said antibody or fragment having the epitopic specificity of the ACT-1 monoclonal antibody.
Dependencies are inferred from the claim text.