Method of reducing the chance of attack of cells in a body by the cellular immune systems

A method of reducing the chance of graft versus host disease in a patient host treated for a malignancy and receiving a bone marrow transplant from a donor and reducing the chance of infection and relapse of the malignancy, comprising the steps of:

• obtaining for cellular selection mononuclear cells containing T-cells from the donor;
• obtaining, from the host, cell derived antigens, including malignancy antigens, recognized by T-cells included in the donor mononuclear cells;
• incubating the mononuclear cells from the donor with host antigens, including malignancy antigens, to thereby activate donor mononuclear cells that are specific to the malignancy antigens;
• obtaining, from the host, cell derived normal antigens recognized by T-cells included in the donor mononuclear cells but not including malignancy antigens;
• incubating activated mononuclear cells from the donor with host antigens not including malignancy antigens and recovering the donor mononuclear cells that do not attach to the host antigens;
• infusing the recovered cells into the host;
• and
• in coordination with infusing the recovered cells into the host, infusing into the host inoculum from the donor which constitutes the bone marrow transplant after substantial depletion of T-cells from the inoculum.