Tumor radiosensitization using gene therapy
AssigneeThe Regents of the University of California
InventorWilliam H. McBride
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Abstract
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method of radiosensitizing a tumor in a subject by administering, at a site other than the tumor, a cell genetically modified to express a cytokine. The invention further provides a method of reducing the severity of a cancer in a subject by administering a cytokine at the site of the tumor or by immunizing the subject at a site other than the tumor with tumor cells genetically modified to express a cytokine, and treating the tumor with radiotherapy.
Claims23
A method of inhibiting the growth of a solid tumor in a mammal, comprising:
- (a) administering at or around the site of a solid tumor in said mammal an expressible nucleic acid molecule encoding interleukin-3, wherein said interleukin-3 is expressed and stimulates an immune response against the tumor, and wherein said tumor has increased radiation susceptibility;
- (b) providing to said mammal a tumor antigen, wherein said tumor antigen is common to said tumor;
- and
- (c) treating said tumor with radiation, wherein the growth of said tumor is inhibited.
A method of inhibiting the growth of a solid tumor in a mammal, comprising:
- (a) administering to said mammal a cell genetically modified to express interleukin-3, wherein said interleukin-3 is expressed and stimulates an immune response against the tumor, and wherein said tumor has increased radiation susceptibility;
- and
- (b) treating said tumor with radiation, wherein the growth of said tumor is inhibited.
A method of inhibiting the growth of a solid tumor in a mammal, comprising:
- (a) administering to said mammal a cell genetically modified to express interleukin-3, wherein said interleukin-3 is expressed and stimulates an immune response against the tumor, and wherein said tumor has increased radiation susceptibility;
- (b) providing to said mammal a tumor antigen, wherein said tumor antigen is common to said tumor;
- and
- (c) treating said tumor with radiation, wherein the growth of said tumor is inhibited.
Dependencies are inferred from the claim text.