Malaria vaccine based upon the addition of a MSA1 peptide
AssigneeGeorgetown University
InventorsEugene A. Davidson, Shutong Yang
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Abstract
The present invention relates to an expression vector which expresses a malaria MSA1 peptide in combination with a signal peptide and anchor peptide in a host animal. The MSA1 peptide is combined with a signal peptide and anchor peptide for expression. Chimeric peptides being expressed with both signal peptides and anchor peptides were the most effective in eliciting an immunogenic response from a vaccinated host.
Claims8
An immunogenic composition comprising a pharmaceutically acceptable carrier and a vaccinia virus expression vector comprising a nucleotide sequence which encodes for an immunogenic MSA1 peptide operably linked to a signal sequence and an anchor sequence, wherein said signal sequence is SEQ ID NO:6 expressed at the N-terminus of the MSA1 peptide and said anchor sequence is SEQ ID NO:8 expressed at or near the carboxy-terminus of said MSA1 peptide.
A method of eliciting an immune response against a MSA1 peptide in a patient, comprising administering to a patient an effective amount of a recombinant vaccinia virus capable of expressing an immunogenic MSA1 peptide operably linked to a signal sequence and an anchor sequence, wherein said signal sequence is SEQ ID NO:6 expressed at the N-terminus of the MSA1 peptide and said anchor sequence is SEQ ID NO:8 expressed at or near the carboxy-terminus of said MSA1 peptide.
An expression vector comprising a nucleotide sequence which encodes for an immunogenic MSA 1 peptide operably linked to a signal sequence and an anchor sequence, wherein said signal sequence is SEQ ID NO:6 expressed at the N-terminus of the MSA1 peptide and said anchor sequence is SEQ ID NO:8 expressed at or near the carboxy-terminus of said MSA 1 peptide.
Dependencies are inferred from the claim text.