Topical antibiotic composition for treatment of eye infection

A pharmaceutical composition suitable for topical administration to an eye, the composition comprising:

• as active agent at least one oxazolidinone antibacterial drug in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of one or more tissues of the eye, and
• at least one ophthalmically acceptable excipient that reduces a rate of removal of the composition from the eye by lacrimation such that a concentration of the active agent in lacrimal fluid of the eye is maintained above the MIC90 for at least about 2 hours following topical application to the eye.

A method of treating and/or preventing a bacterial infection in an eye of a warm-blooded subject, the method comprising:

• administering in each of one or more topical applications to the eye a therapeutically or prophylactically effective amount of a composition comprising as active agent at least one oxazolidinone antibacterial drug and at least one ophthalmically acceptable excipient that reduces a rate of removal of the composition from the eye by lacrimation such that the composition has an effective residence time in the eye of about 2 to about 24 hours.

A method of treating and/or preventing a bacterial infection in an eye of a warm-blooded subject, the method comprising:

• administering in at least one topical applications to the eye a therapeutically or prophylactically effective amount of a composition comprising as active agent at least one oxazolidinone antibacterial drug and at least one ophthalmically acceptable excipient that reduces a rate of removal of the composition from the eye by lacrimation such that a concentration of the active agent in lacrimal fluid of the eye is maintained above the MIC90 for at least about 2 hours following topical application to the eye.

A method of use of a composition in manufacture of a medicament for topically treating or preventing a gram-positive bacterial infection in an eye, the composition comprising as active agent at least one oxazolidinone antibacterial drug and at least one ophthalmically acceptable excipient that reduces a rate of removal of the composition from the eye by lacrimation such that the composition has an effective residence time in the eye of about 2 to about 24 hours.

A pharmaceutical composition suitable for topical administration to an eye, the composition comprising:

• as active agents (a) at least one oxazolidinone antibacterial drug in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of the eye, and (b) at least one antibacterial drug other than an oxazolidinone in a concentration effective for treatment and/or prophylaxis of a gram-negative bacterial infection of the eye.