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US 6,551,578 B2Granted
Modulated release particles for aerosol delivery
AssigneeAeropharm Technology Incorporated
InventorsAkwete L. Adjei, Yaping Zhu
Life of this patent
Estimating the term…
Abstract
A modulated release aerosol formulation is disclosed. The formulation comprises a polysaccharide polymer having a selected medicament associated therewith, a fluid carrier for carrying and delivering the construct and a stabilizer.
Claims25
A modulated release aerosol formulation, which consists essentially of,
- a. polymeric construct comprising a polysaccharide polymer having a selected medicament associated therewith;
- and
- b. fluid carrier for carrying and delivering said construct;
- and
- c. a stabilizer selected from the group consisting of a first stabilizer, a second stabilizer and a mixture of the foregoing stabilizers.
2 more elements
A modulated release aerosol formulation, which consists essentially of,
- a. selected particulate medicament;
- b. particles of a polysaccharide polymer having said medicament associated therewith;
- c. a stabilizer selected from the group consisting of a first stabilizer, a second stabilizer and a mixture of the foregoing stabilizers combined with said particles;
- and
- d. a fluid carrier for carrying and transporting said combined particles.
2 more elements
A metered dose inhaler containing a modulated release medicinal formulation, the formulation consisting essentially of,
- a. a particulate medicament in a therapeutically effective amount;
- b. a polysaccharide polymer with which said particulate medicament is associated to form a particulate polymeric construct;
- c. a fluid carrier for containing and transporting said particulate polymeric construct;
- and
- d. a suitable stabilizer selected from the group consisting of a first stabilizer, a second stabilizer and a mixture of the foregoing stabilizers present in an amount sufficient to stabilize the formulation to prevent settling, creaming or flocculation thereof for a time sufficient to allow reproducible dosing of said associated medicament after agitation of the formulation.
2 more elements
A modulated release aerosol formulation, which consists essentially of:
- a. a selected particulate medicament;
- b. particles of a polysaccharide polymer selected from the group consisting of an alginic acid or a pharmaceutically acceptable salt thereof;
- guar gum;
- gum Karaya;
- gum Benjamin;
- plantago ovata gum;
- agar;
- carrageenan;
- cellulose;
- galaturonic acid or a mixture of any of the foregoing polymers having said medicament associated therewith;
- c. a fluid carrier for carrying and transporting said particles of polymer;
- d. a stabilizer selected from the group consisting of (1) a first stabilizer selected from the group consisting of (a) an amino acid, (b) a derivative thereof and (c) a mixture of the foregoing:
- and (2) a second stabilizer of a water of addition and (3) a mixture of (1) and (2);
- and
- e. cosolvent.
12 more elements
Dependencies are inferred from the claim text.