Tuftsin metallopeptide analogs and uses thereof
AssigneeRhomed Incorporated
InventorShubh D. Sharma
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Abstract
Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of the metal ion-binding portion thereof with a metal ion, resulting in a peptide, peptidomimetic or construct with increased affinity for the tuftsin receptor.
Claims22
A peptide or pharmaceutically acceptable salt thereof comprising a metal ion-binding backbone including two or more contiguous amino acids available for complexing with a metal ion, which peptide is specific for the tuftsin receptor on complexing the metal ion-binding backbone with a metal ion,
- wherein said peptide has a sequence selected from the group consisting of
- D-Arg-Arg-D-Cys-Arg;
- Thr-Arg-Arg-Cys-Arg;
- Thr-Arg-Arg-D-Cys-Arg;
- and
- Thr-D-Arg-D-Arg-Cys-Arg.
A manufactured peptide or pharmaceutically acceptable salt thereof which is specific for the tuftsin receptor upon complexing with a metal ion, said peptide having a sequence selected from the group consisting of
- D-Arg-Arg-D-Cys-Arg;
- Thr-Arg-Arg-Cys-Arg;
- Thr-Arg-Arg-D-Cys-Arg;
- and
- Thr-D-Arg-D-Arg-Cys-Arg.
Dependencies are inferred from the claim text.