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US 6,551,512 B1Granted
Continuous method for separating substances according to molecular size
AssigneeMerck Patent GmbH
InventorsLothar Britsch, Michael Schulte, Jochen Strube
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Abstract
Continuous separation methods, in partricular using SMB methods, are disclosed, in which the analytes are separated by size exclusion chromatography (gel permeation chromatography).
Claims9
A method comprising continuous countercurrent chromatographic separation of analytes wherein the analytes are separated by size exclusion chromatography with no adsorption of the analytes by a sorbent, said separation being based upon calculating net flow ratios of a simulated moving bed method from parameters of checked, calculated effective porosities, residence times;
- and band broadening, thereby allowing stabilization of a raffinate front of the component retained the shortest in the region of Section IV.
Dependencies are inferred from the claim text.