US 6,551,232 B1 · Dosimetry for californium-252(252Cf) neutron-emitting brachytherapy sources and encapsulation, storage, and clinical delivery thereof

Abstract

The present invention discloses a methodology for the characterization and determination of mixed-field dosimetry for 252Cf Applicator Tube (AT)-type medical sources, utilizing ionization chambers, GM counters, and Monte Carlo methods. Unlike the previous methodologies, the present invention discloses a specification of dose to muscle, rather than dose to water, for clinical dosimetry of 252Cf medical sources. A dosimetry protocol, similar to that utilized for ICRU-45, with parameters determined specifically for 252Cf brachytherapy is disclosed. Neutron isodose distributions and data necessary for clinical implementation of 252Cf AT sources are also disclosed herein. Additionally, novel methods for the encapsulation, storage, and delivery/implantation of 252Cf radionuclide sources are disclosed.

Claims16

Dependent claims

A method for the use of a neutron-emitting brachytherapy source, said method comprising:

(a) determining a radiation dose for brachytherapy from a water-based teletherapy dosimetry formalism modified, to produce a modified formalism, to provide dosimetry based upon material characteristics of at least one of tissue and tissue-simulating media instead of water;
and
(b) administering the radiation dose to an individual in need thereof via neutron brachytherapy.

Dependencies are inferred from the claim text.

Facts

Application

09/641,356Filed 17 Aug 2000 · us provisional application

Priority

19 Aug 1999

Granted

22 Apr 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 41/009
Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations: neutron capture…
A61N 5/1001
X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy: using radiation sources introduced into or applied onto the body; brachytherapy
A61N 5/1007
Using radiation sources introduced into or applied onto the body; brachytherapy: arrangements or means for the introduction of sources into the body
G21F 5/015
Transportable or portable shielded containers: for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers

Dosimetry for californium-252(252Cf) neutron-emitting brachytherapy sources and encapsulation, storage, and clinical delivery thereof

Life of this patent

Dosimetry for californium-252(252Cf) neutron-emitting brachytherapy sources and encapsulation, storage, and clinical delivery thereof

Life of this patent

Abstract

Claims16