Devices and methods for the transcutaneous delivery of ions and the electrical stimulation of tissue and cells at targeted areas in the eye

A method for generating negative ions in the uveal and periuveal areas of an eye of a patient comprising the steps of:

• providing a frame having at least one electrode mounted on said frame;
• positioning said frame on the head of the patient to hold said electrode adjacent an orbit;
• and
• applying a voltage to said electrode to generate negative ions in the uveal and periuveal areas of an eye.

A method for electrical stimulation of cells in the uveal and periuveal areas of the eyes of a patient comprising the steps of:

• providing a frame having a first electrode mounted on said frame and a second electrode mounted on said frame;
• positioning said frame on the head of the patient to hold said first electrode adjacent one orbit of the patient and said second electrode adjacent the other orbit of the patient;
• and
• applying a voltage to said electrodes to pass an electrical current from the first electrode, through the uveal and periuveal areas of the eyes, to the second electrode, wherein said voltage is a pulse package having a first sequence of pulses of a first voltage sign, said first sequence of pulses increasing in a substantially linear manner from a zero voltage to an absolute voltage followed by a second sequence of pulses of a second voltage sign, said second sequence of pulses increasing in a substantially linear manner from a zero voltage to an absolute voltage and wherein said second voltage sign is opposite said first voltage sign.