Method for activating peroxisome proliferator activated receptor-γ
AssigneeCity of Hope
InventorBarry Forman
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Abstract
The invention relates to a method of identifying nuclear receptor controlled genes in specific tissues. In particular, the method also provides a method of activating PPARγ nuclear receptor controlled target genes in vivo in a tissue-specific manner.
Claims1
A transgenic mouse predisposed to a spontaneous development of diabetes whose genome comprises a DNA sequence encoding a constitutively active fusion protein comprising a peroxisome proliferator activated receptor-gamma (PPARγ) fused at its N-terminus to the transcriptional activation domain of the Herpes viral VP16 protein, wherein said DNA sequence is operably linked to the uncoupling protein 1 (UCP-1) promoter and wherein said transgenic mouse is resistant to the development of diabetes.
Dependencies are inferred from the claim text.