Compounds and methods for the inhibition of the expression of VCAM-1
AssigneeAtheroGenics, Inc.
InventorPatricia K. Somers
Life of this patent
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Abstract
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
Claims68
A compound of the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the following formula:
- or a pharmaceutically acceptable salt or ester thereof.
A pharmaceutical composition comprising an effective anti-inflammatory treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising an effective anti-inflammatory treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt or ester thereof, in combination with a pharmaceutically acceptable carrier.
A method for the treatment of an inflammatory disorder, comprising administering to a host in need thereof an effective treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.
A method for the treatment of a disorder mediated by VCAM-1, comprising administering to a host in need thereof an effective treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.
A method for the treatment of rheumatoid arthritis, comprising administering to a host in need thereof an effective treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.
A method for the treatment of arthritis, comprising administering to a host in need thereof an effective treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.
A method for the treatment of cardiovascular disease, comprising administering to a host in need thereof an effective treatment amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, optionally in combination with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.